ACSS2 and cystic fibrosis: Several genes involved in fatty acid metabolism and the tricarboxylic acid cycle have been shown to be significantly upregulated in high cell density P. aeruginosa infections in the lungs of cystic fibrosis patients, and acsA was more highly expressed in a sputum isolate of P. aeruginosa than it was in PAO1 grown on citrate [68].