We first examined expression of the adipokine receptors, LEPR (functional leptin receptor), ADIPOR1 and ADIPOR2 (adiponectin receptors) in four cell lines chosen to represent different states of progression or subtypes of breast cancer: MCF10A (immortal, non-cancerous), MCF10AT1 (isogenic cancerous pair to MCF10A, transformed in vitro), MCF7 (luminal, hormone receptor positive, non-metastatic) and MDA-MB-231 (basal, hormone receptor negative, metastatic). Here, LEPR is linked to breast cancer.