The marked changes in APP levels that occur during infection and inflammation allows them to serve as important diagnostic and prognostic markers for various infectious and inflammatory diseases.1 In the present study, we investigated the effect of melatonin on expression of the positive APPs SAA, haptoglobin, CRP, ceruloplasmin, and α-1 antitrypsin, and of the negative APP fibrinogen in LPS-stimulated bMECs. This evidence concerns the gene CRP and infection.