We can model the dynamics of the necrotic cells and of HMGB-1 by the following equations:∂NC∂t+∇·(uNC)}velocity-δNC∇2NC}difusion=λNCCC}derivedfromlifecancercells-dNCNC}removal,∂H∂t-δH∇2H}difusion=λHNCNC}releasedfromneroticcancercells-dHH}degradation,where λNCC is the rate at which cancer cells become necrotic and λHNC is the rate at which necrotic cells produce HMGB-1. The gene discussed is HMGB1; the disease is cancer.