KCNE1 and cardiovascular disorder: In addition, several ion channels are modulated by STS and its precursor Tanshinone IIA in some cardiovascular disease models, such as human cardiac KCNQ1/KCNE1 (I-Ks) K+ channels [28], high conductance Ca2+ activated K+ channels (BKCa) [29], KV2.1 and KV1.5 [30].