CCND1 and B-cell non-Hodgkin lymphoma: MiR-15b and 16–2 have been shown to modulate the gene expression of various cyclins and growth factors, including CCND1 and CCND2 (encoding Cyclin D1 and D2, respectively) as well as IGF1R (encoding the insulin-like growth factor 1 receptor); this regulatory mechanism affects proliferation and anti-apoptosis processes, as shown in mouse B cells and in miR-15b/16-2 knockout mice, leading to development of B-cell lymphomas in the latter [25].