Finally, we identified two missense mutations, including a reported rare variant c.55A>G (p.Asn19Asp) and a de novo variant c.238C>A (p.Leu80Ile), in two sporadic patients with congenital HL unrelated to GJB2, GJB3 and mtDNA mutations. This evidence concerns the gene GJB2 and Hodgkins lymphoma.