We found that after adjusting for age, sex, race/ethnicity, BMI, urinary creatinine levels, and smoking duration (Model 1), both TNE and CYP2A6 activity were associated with an increase in lung cancer risk (HR per log-TNE increase = 1.83; 95% CI: 1.24–2.71 and HR per log-CYP2A6 activity increase = 1.60; 95% CI: 1.20–2.14). Here, CYP2A6 is linked to lung carcinoma.