In addition they show a distinctly altered lipoprotein pattern, reduced hepatic and plasma HexCer levels, a decreased hepatic FFA to TAG ratio and transcriptional changes of obesity associated genes in liver, including delta-9 desaturase Scd1. It has to be noted that the re-expression of ATP10D was conferred by transgenic introduction of a BAC containing the Sv129 Atp10d-gene. This evidence concerns the gene SCD and obesity due to melanocortin 4 receptor deficiency.