In an observational study among 315 chronic lymphocytic leukemia (CLL) patients, targeted deep sequencing of 18 core complex genes within the NF-κB pathway found that the most frequently mutated genes was NFKBIE; further screening revealed that truncated NFKBIE predominated in patients with poor prognosis [57]. The gene discussed is NFKBIE; the disease is B-cell chronic lymphocytic leukemia.