In neuropathologically confirmed PD, the APOE ε4 allele is more prevalent in cases with higher burdens of coexisting Aβ amyloid pathology [47, 48], and the entorhinal, temporal, and parietal cortices could be particularly vulnerable to Aβ amyloid pathology in APOE ε4 carriers with PD [34]. Here, APOE is linked to Parkinson disease.