PPIG and Pythiosis: Fig 3(A) to 3(I) demonstrates the main histological lesions and immunohistochemistry of pythiosis in the kidneys, liver and lungs of BALB/c mice from the immunosuppressed (PI+CYP+HCA) group that was subcutaneously infected with P. insidiosum. Focally extensive coagulation necrosis areas associated with severe multifocal thrombosis in arteries, arterioles and venules were similarly evident in the kidneys and liver (Fig 3B and 3E).