In contrast, there was no significant difference in T575 phosphorylation between HCC1937 cells and those transfected with the I26A mutant form of BRCA1 (HCC1937+I26A; p = 0.1), although we note a trend for the I26A mutant protein to cause a worsening of the defect, as was also seen in the context of breast cancer cell motility [33]. The gene discussed is BRCA1; the disease is breast cancer.