Our present study demonstrated that the ethanolic extract of Angelica Dahurica—ADEE has a beneficial role in improving diabetes-impaired wound healing via its direct effects on neovascularization and inflammation resolution, and the angiogenic role of ADEE is exerted through pathways involving ERK1/2 and Akt/eNOS phosphorylation and NO production. Here, AKT1 is linked to diabetes mellitus.