EDN1 and Decreased liver function: The overall correlation between CT-pro-ET-1, TNF-α and IL-6 and liver dysfunction showed Spearman correlation coefficients of -0.434 (CT-pro-ET-1; P <0,001, Fig 3A), -0.515 (TNF-α; P <0,001, Fig 3B) and -0.590 (IL-6; P <0,001, Fig 3C), respectively.