ALB and age-related macular degeneration: In the boxplot representations for Coimbra (Fig 4) and Boston (Fig 5) cohorts, a number of small metabolite variations (some only qualitative in nature) emerge as potentially differentiating controls from early AMD, namely: 1) acetate, creatine, dimethyl sulfone, cholesterol, HDL-choline and unsaturated fatty acids in Coimbra subjects and 2) glutamine, histidine, unsaturated fatty acids and albumin, in Boston subjects (highlighted metabolite names in Figs 4 and 5).