SPTLC1 and neoplasm: Overall, an average of 5.75 non-synonymous variants were identified per tumor, ranging from two variants (SpT4, near-diploid), five (SpT6), seven (SpT8) to nine (SpT1) per tumor, which indicates an overall genome-wide estimate of 0.2 (0.12–0.25) somatic SNVs/Mb (Fig 3A).