In kidneys, TLR4 and TLR2 promote injury in response to renal ischemia-reperfusion[6, 14], TLR4 is activated in the renal tubules of human kidneys with diabetic nephropathy, where it promotes tubular inflammation[15]; however, the precise role of TLR4 in kidney tubular cell repair under high glucose conditions remains unknown. The gene discussed is TLR4; the disease is ischemia.