In addition, few studies have analysed the role of Single Nucleotide Polymorphisms (SNPs) in this gene and its promotor, although Yokoo et al. (2016) suggested that some SNP alleles in the NRF2 gene could increase CRC risk based on previous studies of these polymorphisms and the risk of ulcerative colitis [36]. The gene discussed is NFE2L2; the disease is colorectal carcinoma.