SOX10 and malignant peripheral nerve sheath tumor: Among the 20 most-downregulated genes are 4 NF- and/or MPNST-associated genes (S12 Table), the transcriptional regulator SOX10, needed for neural crest multipotent cell and peripheral nervous system development, the extracellular matrix glycoprotein TNXB, the cell-cell adhesion Ca2+-dependent cadherin CDH19, specific to myelin-forming cells, and the Ca2+-binding S100B, whose inhibition is associated to MPNST transformation [33].