Inflammatory factors are increased to a greater extent in overweight/obese women compared to normal weight women.[28, 34] These inflammatory markers (TNF-α and interleukin-6) can be secreted from adipocytes and stimulate the liver to produce C-reactive protein (CRP).[35] Our study shows that lipids do not mediate the association between obesity and BP course during pregnancy. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.