CRP and ischemia: Given the unexpected predominance of HFpEF hospitalization at 6-year follow-up in WISE [3, 4], we investigated the relationships between inflammatory markers [interleukin-6 (IL-6), C-reactive protein (hs-CRP), and serum amyloid A (SAA)] and longer-term adverse outcomes in this unique population of patients with signs and symptoms of ischemia with non-obstructive CAD and preserved EF as part of the Women’s Ischemia Syndrome Evaluation (WISE) study sponsored by the National Heart, Lung, and Blood Institute (NHLBI).