Given the unexpected predominance of HFpEF hospitalization at 6-year follow-up in WISE [3, 4], we investigated the relationships between inflammatory markers [interleukin-6 (IL-6), C-reactive protein (hs-CRP), and serum amyloid A (SAA)] and longer-term adverse outcomes in this unique population of patients with signs and symptoms of ischemia with non-obstructive CAD and preserved EF as part of the Women’s Ischemia Syndrome Evaluation (WISE) study sponsored by the National Heart, Lung, and Blood Institute (NHLBI). Here, IL6 is linked to coronary artery disorder.