For example, similar shifts in IgE curves have been documented in populations with different soil transmitted helminth transmission [12], salivary IgG and IgA norovirus assays have been developed [52], and NTDs such as trachoma [53], dengue [54], and chikungunya [55] all have well-defined antigens that would be amenable to this methodology. This evidence concerns the gene CD79A and dengue disease.