CRHR1 and bipolar disorder: Furthermore, CSF AVP was increased in manic patients compared with depressed, schizophrenic and healthy controls [113] and in bipolar patients taking lithium compared to healthy controls [114], and an association was recently found between the TT genotype of rs28536160 polymorphism of the AVPR1b gene and bipolar disorder with psychotic features and also with genotype CC of rs1293651 polymorphism of CRHR1 gene [115].