TRIM45 was reported to negatively regulate the MAPK signaling pathway by inhibiting RACK1/PKC complex formation.18, 19 It also negatively regulates NF-κB signaling.20 Although TRIM45 mRNA is highly expressed in the brain of human adult and embryonic tissues,18 its function in primary CNS tumors has not been investigated yet. The gene discussed is TRIM45; the disease is central nervous system neoplasm.