Several evidences confirmed that most of the cancer cells consume more glucose and create a metabolic reprogramming that is essential for quick proliferation and survival, through substantial alterations in several energy metabolism pathways, including glucose transport, glycolysis and pentose phosphate pathways (PPP).1, 2, 3 Alterations in glucose metabolism of cancer cells is directly regulated by several oncogenic pathways, including the PI3K/Akt, Myc, or hypoxia-inducible factor (HIF) pathways which serve to increase the glycolysis and consecutively promotes cell proliferation.4, 5, 6. The gene discussed is AKT1; the disease is cancer.