In humans, it has been shown that SDF-1 is expressed in the lung during acute lung injury.13 For the first time, we determined the pivotal role of the receptors of SDF-1—CXCR4 and CXCR7—in acute pulmonary inflammation and linked their anti-inflammatory potential to A2B-receptor signalling. The gene discussed is CXCL12; the disease is inflammation.