HMGCR and Autoimmunity: Some important prenylated proteins include members of the Ras superfamily of small GTPases, such as Ras and Rho, involved in proliferation and differentiation processes of cells.2 To better understand the role of statins in autoimmunity and elucidate their effects on HMGCR and other putative targets, we generated a new mouse strain that enables tissue-specific deletion of HMGCR via Cre/loxP system.