While CCL5 can bind to CCR1, CCR3, and CCR5, we revealed that the paracrine CCL5-induced cell migration in colon cancer cells was mainly mediated by CCR1, given that CCR1 antagonist completely abolished the increased migration in colon cancer cells in response to CCL5 (Figure 3d). This evidence concerns the gene CCR5 and malignant colon neoplasm.