Moreover, in murine studies, Akt2 has been suggested to play a critical role in the expansion of visceral adipose tissue on exposure of mice to a high-fat diet, and the previous report of obesity in patients with the AKT2 p.Glu17Lys mutation has been suggested to support an important cell autonomous role of AKT2 in adipocyte development (15). This evidence concerns the gene AKT2 and obesity due to melanocortin 4 receptor deficiency.