TP53 and Li-Fraumeni syndrome: iPSCs have also been generated from human pancreatic ductal adenocarcinomas152, Multiple endocrine neoplasia type 2A (MEN2A)153, bladder cancer cell lines154 and cells from an individual with Li Fraumeni syndrome, a congenital cancer predisposition genotype in which one allele of the p53 gene is mutated155.