This was caused by about six times higher basal level of lnc-EGFR in HCC patient CD4+ T cells than normal healthy controls; knockdown of the endogenous lnc-EGFR by its shRNA restored EGFR ubquitination in response to EGF (Fig. 4b and Supplementary Fig. 10a,b). Here, CD4 is linked to hepatocellular carcinoma.