Tumour growth was dramatically suppressed by the tumour-cell-vaccinated DCs; however, this antitumor effect was strongly attenuated by the cooperation of lnc-EGFR-infected CD4+ T cells, but was rescued by EGFR knockdown or lnc-EGFRΔR1 (Fig. 7a and Supplementary Fig. 17a). Here, CD4 is linked to neoplasm.