The biological effect of lnc-EGFR was further elucidated in vivo by orthotopic or subcutaneous tumour transplantation with adoptive cell transfer in non-obese diabetic/severe combined immune deficiency (NOD/SCID) mice using CD4+ T cells transduced with the control vector, lnc-EGFR, lnc-EGFR+EGFRshRNA or lnc-EGFRΔR1, and 97H-cell-vaccinated DCs. This evidence concerns the gene EGFR and Immunodeficiency.