Therefore, the expression profiles of both mRNAs and lnc-RNAs in CD4+ T cells isolated from HCC tissues and the PBLs of HCC patients and healthy controls were analysed, and a lnc-RNA/mRNA network was built up and discovered that there is a forward-feedback loop, lnc-EGFR-EGFR-NF-AT1/AP1-lnc-EGFR, in Tregs in HCC. This evidence concerns the gene FOS and hepatocellular carcinoma.