Similar results were obtained with immunohistochemical staining: the percentage of Foxp3 and the expression of EGFR were significantly higher in the infiltrating T lymphocytes in the lnc-EGFR-transfected group than in the tumour tissues containing the vector-, Lnc-EGFR+EGFRshRNA or lnc-EGFRΔR1-transduced CD4+ cells; IFN-γ decreased dramatically when lnc-EGFR-transduced CD4+ cells were present. The gene discussed is FOXP3; the disease is neoplasm.