In some experimental animal studies, tranilast has been shown to prevent the c of coronary arteries after percutaneous transluminal coronary angioplasty (PTCA) [35], suppress neointima development after stenting [36], inhibit fibrosis in postmyocardial infarction and collagen production in cardiac fibroblasts by attenuating myocardial TGF-β1 expression [37], and attenuate TGF-β-induced collagen synthesis by cardiac fibroblasts in diabetic cardiomyopathy [38]. This evidence concerns the gene TGFB1 and diabetic cardiomyopathy.