It has been demonstrated that flow restriction-induced venous thrombosis was more common in apo A1−/− mice as compared with wild-type mice, and intravenous infusion of human apo A1 prevented venous thrombosis in wild-type mice but not in mice lacking scavenger receptor B type I or endothelial nitric oxide synthase [44]. The gene discussed is NOS3; the disease is Venous thrombosis.