However, Tian et al. [24] indicated that GP73 elevated not only in HCC but also in other chronic liver diseases such as hepatic cirrhosis and hepatitis; even more, the concentration of GP73 in HCC (median = 107.3 μg/L) was significantly lower than hepatic cirrhosis (median = 141.2 μg/L) patients, but their conclusions may suffer from sample selection biases. This evidence concerns the gene GOLM1 and hepatocellular carcinoma.