Novel biomarkers are urgently needed for the screening of HCC to reduce its high mortality; many studies have reported that lens culinaris agglutinin reactive AFP (AFP-L3) and Golgi protein 73 (GP73) are effective for the HCC early diagnosis [9–11], but there has been a lack of clinical follow-up from hepatic cirrhosis stage to HCC. Here, GOLM1 is linked to hepatocellular carcinoma.