The risk factors analysis showed that incidence rate of HCC in patients with high AFP, AFP-L3, ALT, and AFP-L3/AFP levels were extremely significantly higher than that those with normal levels (RR = 2.99, p = 0.000; RR = 2.92, p = 0.000; RR = 2.72, p = 0.001; RR = 2.34, p = 0.003). Here, GPT is linked to hepatocellular carcinoma.