PLAT and Stroke: Accumulating evidence suggests using tissue plasminogen activator (tPA) therapy within this therapeutic window (4.5 h post stroke) may be beneficial, however, this treatment involves risk and is therefore limited in its application (Graham, 2003; Hess and Borlongan, 2008; Yang et al., 2009; Eissa et al., 2012; Duncan et al., 2015).