In transgenic mice expressing mutant alfasunyclein as a model for PD, the administration of salubrinal inhibiting the PPP1R15A/GADD34 phosphatase inducing phospho-eIF2α levels was found to be neuroprotective suggesting an involvement of the PERK pathway in dopamine neuron degeneration (Colla et al., 2012). Here, PPP1R15A is linked to Parkinson disease.