The insulin resistance syndrome is characterized by glucose intolerance, hyperinsulinaemia, dyslipidemia, abdominal obesity and hypertension [1] Insulin resistance is a fundamental abnormality in the pathogenesis of type 2 diabetes and atherosclerotic cardiovascular disease (CVD) [1–3] Insulin resistance disturbs the functions of insulin target organs, such as adipose tissue, which is related to glucose metabolism, lipogenesis, and adipokine secretion [4]. This evidence concerns the gene INS and Glucose intolerance.