On the contrary, mean plasmatic value of NT-pro-BNP was 843.40±938.05 pg/ml in sinus rhythm patients (group 2), significantly lower than NT-pro-BNP levels in heart failure and atrial fibrillation patients (group 1)- 1639.12±993.03 pg/ml, (P=0.0001). The gene discussed is NPPB; the disease is heart failure.