As shown in Table 3, serum Klotho and 25-OH Vit D concentrations were significantly lower in the scleroderma patients than those in the control group: [3.47 (2.30–11.07) vs. 4.28 (2.99–7.88), ng/mL; P<0.001] and [15.01±4.71 vs. 27.23±8.66, ng/mL; P<0.001], respectively. The gene discussed is KL; the disease is scleroderma.