TLR4 and hypertensive disorder: Adjusted for age, sex, culprit lesion, fasting glucose, HbA1C, LDL cholesterol, high-sensitive CRP, and history of HTN, DM, and corrected CAD.  Marked TLR4 expression in atherosclerotic plaques, oxidative stress upregulates macrophage TLR4 expression, perhaps an association between TLR4, inflammation and coronary atherosclerosis. Activation of TLR4 signal may induce miR-146a/b expression as a negative regulator and induce progression of coronary atherosclerosis.