Overall it seems likely that genetic variants in NRF2 affect both the risk of developing neurodegenerative disorders such as PD and the age of onset, but as different sets of SNPs were included in these studies, as well as the differential distribution of haplotypes in populations with different ethnicity, it is difficult to pinpoint what combination of SNPs is responsible for the reported associations. The gene discussed is NFE2L2; the disease is Parkinson disease.