Activation of cell death pathways such as NF-κB and impairment of pro-survival signaling pathways are triggered by hypoxia, free radicals, and inflammatory mediators (Interleukin-1β and Interleukin-6) in cerebral ischemia (Ridder & Schwaninger, 2009). This evidence concerns the gene NFKB1 and Cerebral ischemia.