Some studies have proposed the deleterious effect of LH on senile memory disturbances, such as Alzheimer disease, and suggested that LH may potentiate the pathological mechanisms of these disorders (Meethal, Smith et al., 2005; Casadesus, Milliken et al., 2007; Webber, Casadesus et al., 2007; Craig and Murphy, 2009; Palm, Chang et al., 2014; Blair, Palm et al., 2016). This evidence concerns the gene PLOD1 and early-onset autosomal dominant Alzheimer disease.