This study aims to evaluate the effect of treatment with triptorelin, a sustained release GnRH agonist, which decreases LH release (Asch, Rojas et al., 1985), with or without HRT (β-estradiol in females and testosterone in males) on Novel Object Discrimination (NOD) memory and anxiety in gonadectomized rats. Here, GNRH1 is linked to Anxiety.