A prospective study reported that after H. pylori eradication, the fasting plasma insulin level (p < 0.01) and HOMA-IR (p < 0.01) were significantly lower than before treatment, indicating that H. pylori eradication improved IR and may prevent the occurrence of MS, and NAFLD (Abenavoli et al., 2013; Dogan et al., 2015). The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.