In line with our findings, a phase I/II clinical trial in breast cancer patients treated with a recombinant HER2 protein adjuvanted in AS15 (Limentani et al., 2016) recently reported the best humoral response (higher frequency of responders and higher anti-HER2 geometric mean concentration) in the group received the highest dose of vaccine (500 μg) in comparison with the lowest one (20 μg). The gene discussed is ERBB2; the disease is breast cancer.