Familial ALS/FTD mutations in CCNF were present at frequencies ranging from 0.6% to 3.3% (Williams et al., 2016), similar to the frequency of mutations in TARDBP and FUS (Sreedharan et al., 2008; Vance et al., 2009), and 10 novel missense mutations were identified in diverse geographic populations. Here, TARDBP is linked to frontotemporal dementia.