Obesity and PCOS are linked as a result of anumber of ways major ones include an altered lipid profile,excess adipose tissues – mass /cells; lymph tissues, increasedability to absorb fat, excess androgen hormone levels, use ofpsychiatric medications, altered hormonal profile and its linkwith brain, mainly hypothalamus, increased insulin resistanceand its association with cAMP signaling, PI3K pathway andinvolvement of endometrial cells of obese PCOS women in othersignificant pathways, for example, Wnt, Shh, Etk etc. The gene discussed is SHH; the disease is polycystic ovary syndrome.