There are 28 differentially expressed genes namely KIAA0040,CCDC3, CXCL12, SLITRK6, ANKFN1, ATP8B1, LRRTM4,ROBO2, EPHA6, GPAT3, PDLIM5, HHIP, EPHA5, NDNF,SLC27A6, FGF10, PLA2G7, ADGRF5, AHR, HGF, WNT2, NRG1,ANGPT2, FREM1, OGN, PAPPA-AS1, PAGE4 and GABRA3were identified between both the groups, i.e. obese womenwithout PCOS and obese women with PCOS with the adjusted pvalueof 0.05 and FC value of 0.06. The gene discussed is NDNF; the disease is polycystic ovary syndrome.