It has been shown that diabetic patients with clinical proteinuria are accompanied by decreased urinary and serum levels of TTP and increased levels of IL-6 and IL-18, and that decreased TTP expression might occur prior to the increase in IL-6 and IL-1816, suggesting that TTP is involved in the inflammatory response in DN and can be developed as a marker for diabetic kidney damage16. This evidence concerns the gene ZFP36 and liver dysplastic nodule.