MAVS and viral infectious disease: Additionally, polymorphisms in retinoic acid inducible gene 1 (RIGI), a member of the RNA-helicase like receptors [RLRs]14, 15, and IPS116 (IFN-β promoter stimulator 1, alternatively named MAVS: mitochondrial antiviral-signalling protein/virus-induced signalling adapter), an intracellular adapter protein that mediates RLR signalling, are linked to type-I IFN deficiency in man and may therefore underlie susceptibility to viral infections.